Palmitoylethanolamide (PEA) is a naturally occurring fatty acid that has been studied to show neuroprotective, anti-inflammatory, cardioprotective and analgesic pain relief properties

PEA binds to a receptor in the cell nucleus called peroxisome proliferator-activated receptor alpha (PPARa). This plays an important biological role within cells in response to pain.

PEA has an affinity for the CB1, CB2 and GPR55 cannabinoid receptors as well as the TRPV1 capsaicin receptor. It also reduces cyclooxygenase-2 (COX-2) expression and inhibits the release of mast cell mediators such as histamine and TNF-alpha. 

All of this means PEA may assist in reducing, or relieving neuropathic pain and chronic/acute inflammation.

Dosage: 

I capsule a day or as directed by your health care professional